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Clinical trial data from withdrawal studies (such as SURMOUNT-4) demonstrate that patients regain weight after discontinuing GLP-1 receptor agonists and related medications

NAFLD-associated chronic low-grade inflammation responds to L-carnitine supplementation through reduced hepatic pro-inflammatory cytokines (e.g., IL-6), increased anti-inflammatory cytokine IL-10, and downregulation of key inflammatory pathway components (TLR4, NF-B, JNK) (28)
