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Both MAPK/ERK1/2 and the pro-survival PI3K/Akt pathways are stimulated by IGF-I, IGF-2, and activated IGF-1R in cumulus granulosa cells (60)
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In vitro studies using endothelial cell models have demonstrated effects on fibroblast migration rates, endothelial cell tube formation in angiogenesis assays, and cytoprotective mechanisms in cell culture models exposed to oxidative and chemical stressors
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