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The production of NO by NOS2 (in micromolar amounts) is much higher and more sustained than by other NOSes, thereby making NOS2 an important player in regulating inflammation and infection ( 4 ) and ferrous iron (Fe 2+ )

RPI promotes tumor growth and colony formation by negatively modulating protein phosphatase 2A (PP2A) to activate extracellular signal-regulated kinase (ERK) signaling pathways (100)

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In a study with osteoarthritis patients (see section 5.2 Distribution into blood cells), steady state serum concentrations were determined after intake of 200 mg Pycnogenol per day (34)