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This evidence is further supported in animal models of depression (Tuon et al., 2021)

In addition, supplementation with 200 mg/kg L-theanine improves the antioxidant status in the blood by increasing the levels of SOD, GSH-Px, and CAT, thus enhancing the antioxidant capacity and reducing acute oxidative stress in broilers [77]

In cell culture systems, the upregulation of these heat shock proteins similarly caused reductive stress with increased GSH and decreased ROS [48, 49]

Here's a general guideline for oral glutathione dosage based on body weight: 500 mg to 1,000 mg per day Suitable for people under 60 kg (132 lbs) 1,000 mg to 2,000 mg per day Recommended for those between 6080 kg (132176 lbs) 2,000 mg or more per day Suggested for people over 80 kg (176 lbs) For optimal results, many users pair glutathione with vitamin C (5001,000 mg daily), which helps boost its absorption and antioxidant effects