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Free Radical Res 55(1112):10481061 Lei L, Zhang F, Huang J, Yang X, Zhou X, Yan H, Chen C, Zheng S, Si L, Jose PA, Zeng C (2023) Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-B pathway

DAMPs usually activate the innate immune response and macrophages are recruited and activated to secrete various mediators such as macrophage inhibitory protein-1, monocyte chemoattractant protein-1, and IL-8, leading to interstitial inflammation in the kidney [108]

8 Of these, trimethylamine N-oxide (TMAO) is an important and well-studied metabolite

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