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Su LJ, Jiang XF, Yang C, Zhang JH, Chen B, Li YM, et al

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When efferocytosis is impaired, and adipocyte apoptosis increases in morbid obesity, metabolic syndrome, and T2DM, apoptotic bodies undergo secondary necrosis, releasing DAMPs that amplify local inflammation and reinforce a self-sustaining loop between adipose remodeling, immune activation, and insulin resistance [967,968,969,970]

Autophosphorylation of OsVIRK1 maintains its protein accumulation To assess whether OsVIRK1 is an active kinase, we expressed and purified the cytoplasmic kinase region of OsVIRK1 fused to the MBP tag (MBP-VIRK1C) from Escherichia coli