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Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: results of a pilot clinical trial

Switching to preservative-free formulations typically resolves the issue for people who need b12 but react to standard preparations

doi: 10.1111/j.1556-4029.2008.00973.x