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It causes chronic aching pain in the joints and muscles around the body
Next, the dipeptide reacts with L-glycine by the enzyme glutathione synthase (Figure 1(a), [23])
Once stabilized, NRF2 translocates to the nucleus, binds to AREs, and induces cytoprotective genes such as HO-1 , NQO1 , SLC7A11 , and GPX4 , which restore redox balance and limit lipid peroxidation [23]
Studies involving ferroptosis in neurodegenerative disorders are generally aiming to inhibit ferroptosis cell death
