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These findings suggest that ellagitannins may modulate disease development through the gut microbiota-bile acid axis

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10.1016/S0092-8674(00)81067-3 Kellerer M, Mushack J, Seffer E, Mischak H, Ullrich A, Haring HU: Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells)

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The germ gets into the cells, so you need a second drug to get into the cells

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