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While malfunctions of NO-system significance are generally implicated in various disturbances, the presented findings (i.e., schizophrenia) claim both decreased and increased NO-system function in etiopathology and, thereby, controversy in therapy, either L-NAME or L-arginine [59,70,124]

It also plays its own role in skin health by supporting natural collagen production and inhibiting tyrosinase, the enzyme responsible for melanin synthesis

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Such modulation may manifest through alterations in the release of neurotransmitters or changes in membranes, indirectly influencing neuronal excitability and the flow of neural information