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Characterization of the GSTU10-10 isoenzyme revealed that it has an antioxidant catalytic function by acting as a hydroperoxidase and has a very low K m for GSH suggesting that GSTU10-10 is able to perform efficient catalysis under conditions where GSH concentrations are low, e.g., during oxidative stress (Skopelitou et al., 2015)

You could use lysates from lung cancer cells to try to identify novel interactions in this relevant cell type

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Dysfunctional renin-angiotensin system (RAS) was previously associated with accelerated aging as excess ANG II induces telomere attrition as demonstrated in both severe COVID-19 illness and children with Hutchinson-Gilford progeria, a syndrome of accelerated aging (Regenass et al., 1994