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Addingly, another study not only showed increased iron concentration in SN pars compacta of early-stage PD patients compared to controls, but in those with late-stage PD apart from affecting SN pars compacta, other areas such as red nucleus and globus pallidus became involved suggesting a regionally progressive accumulation that is consistent with the stage of the disease ( in vivo assessment of iron dysregulation and supports the thesis that region-specific brain iron accumulation could represent a valuable biomarker in diagnosis, prognosis and disease monitoring in PD and parkinsonism ( Potential association between iron metabolism and T2DM pathobiology has been studied in vivo on a Chinese population of T2DM of middle-aged and elderly patients with evidence of a linear correlation between ferritin levels and risk of developing T2DM (Sun et al., 2013)

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