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B12, oral therapy could not only save resources and time, but may also be preferable for patients with coagulation issues (coagulopathies or on blood-thinning medications) and those who are adverse to injections, for example, elderly patients with sarcopenia for whom i.m

Mechanistically, HGF-induced synapse formation is mediated by PI-3K and not MAPK activation, as inhibition of the PI-3K/AKT pathway affects synaptogenesis, while blocking MAPK/ERK does not decrease synapse density and only affects dendritic growth (Eagleson et al., 2016)