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49,51,52 In addition, imbalanced glutamate and GABA activity may contribute to a link between depression and chronic pain

Ethics declarations Ethics approval and consent to participate Manuscripts reporting studies involving human participants, human data, or human tissue must: The procedures and data collections in human study have been approved by Institutional Review Board of National Taiwan University Hospital (201507055MINC, 201712030RIND), and all participants signed a written informed consent form

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4.4 Betaine in neurodegenerative diseases McDonough and colleagues recently reported that BHMT is expressed in the brain and betaine enhances neuronal respiration and promotes oligodendrocyte maturation by modulating histone and DNA methylation