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We believe that all the topics discussed in this review, with clear mechanisms and pathogenesis roles of oxidative stress in the progression of DNP, may be promising subjects for further studies on DNP, which open up new platforms for the proper management of DNP and neuropathic pain

The second step in GSH synthesis is catalyzed by glutathione synthetase (encoded by GSHS ) and involves the addition of glycine to -Glu-Cys ( hGSHS gene ( cis -regulatory elements are present in the promoter regions of both GSHS and hGSHS , indicating that, in legumes, they may either perform different functions or perform similar functions that are separated temporally or spatially ( Medicago sativa , GSH is associated with meristematic cells, cell-cycle activation, and the induction of somatic embryogenesis, while hGSH is associated with differentiated cells and embryo proliferation ( Lotus japonicus , meanwhile, GSHS is expressed only in nodules, whereas hGSHS is also expressed in leaves and roots ( M

The TNF gene helps regulate inflammation, and differences in TNF activity can shape how the body responds to stress and repair