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Acknowledgement The authors extend their appreciation to the researchers supporting project number (RSP-2021/221) at King Saud University, Riyadh, Saudi Arabia
Some researchers have shown that metformin activates AMPK and triggers the downstream GSH system to slow DOX-mediated oxidative impairment in the myocardium [225, 226]

Mar 29 2021;12(4)doi:10.3390/genes12040505 Marchand A, Drouyer M, Sarchione A, Chartier-Harlin MC, Taymans JM

Despite extensive research, no definite biomarker for diagnosis or treatment has been detected (6)
