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Specifically, higher exercise intensity is associated with elevated plasma levels of IL-6, whereas levels of Interleukin-10 (IL-10) remain unchanged from baseline before exercise [149]

And in the study of the damage of dopaminergic neurons by paraquat and mancozeb, it was found that NADPH oxidase activation caused lipid peroxidation, which led to ferroptosis in SH-SY5Y cells (Hou et al., 2019)

Emerging therapies targeting ferroptosisincluding inhaled nanoparticles delivering GPX4 mRNA or siRNA against ER/ACSL4show promise in preclinical models by selectively inhibiting lipid peroxidation without systemic immunosuppression ( 5 Immune cells and ferroptosis in asthma Immune cells are central contributors to the pathogenesis of asthma, but their roles extend beyond simple pro- versus anti-ferroptotic categorization

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