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For an in-depth understanding, you can refer to studies from Grand View Research, Mordor Intelligence, and Statista linked below

26 patients completed the entire follow up period and premature drop-out was due to death (n = 11), deteriorating health (n = 9), nausea (n = 8), excessive demand (n = 5), diarrhea (n = 2) or miscellaneous symptoms (n = 7)
Sure, it can get slightly more expensive than your go-to pay site, but theres more to it
Am J Surg 186 : 641647 Putnam JB et al
