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Description
Science 353 , 12491253 (2016)
doi:10.15227/orgsyn.006.0072
Pegtibatinase, also known as OT-58 or TVT-058, is a recombinant human CBS catalytic core (amino acids 1413) that has been modified with the addition of polyethylene glycol (PEG) and lacks the CBS autoinhibitory regulatory domain, yielding a constitutively active, predominantly dimeric enzyme
Moreover, results from animal studies have consistently demonstrated the detrimental effects of oxidative stress on central nervous system 15,16
