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39 MayoJ

While early activation may serve a protective role by clearing cellular debris, prolonged or excessive activation leads to a shift in phenotype, marked by altered expression of core markers, including the upregulation of inflammatory genes and downregulation of homeostatic functions, which plays a critical role in disease progression and therapeutic targeting (Paolicelli et al., 2022)

doi: 10.1155/2017/1602074 100 SongPRamprasathTWangHZouMH

Prevention: Apply an appropriate catheter securement device
