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Reitz C, Mayeux R

CVD is characterized by inflammation induced atherosclerotic complications, resulting from an increase of lipid particles to the endothelial cells causing foam cell and the resultant plaque formation ( Other comorbidities associated with T2D are hypertension, dyslipidemia, and renal insufficiency ( As T2D progresses, hyperinsulinemia, hyperglycemia, and oxidized LDL culminates in endothelial cell dysfunction and apoptosis ( Complicating CVD in T2D patients is the common association of combined hyperlipidemia, a pro-atherogenic lipid disorder, characterized by high levels of LDL, triglycerides (TGs), and decreased levels of HDL ( Current pharmacological therapies for T2D, when in conjunction with CVD, attempt to reduce associated risks through tight glycemic control, dietary changes, and statin drugs