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Compounds 14 and 15 reduced TNF- levels by 73.73% and 70.64%, respectively, as well as the protein expression of NF-B, TNF-, and COX-2, compared to indomethacin

Both metals contribute to ROS production via the Haber-Weiss and Fenton reactions, ultimately generating radical species identical to those produced by iron alone [Table 2]

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Serum folate reflects short-term changes in diet and may be altered by recent meals, so fasting for about six hours beforehand is required, and repeated testing is needed to identify true deficiency