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The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus
Also, because checkerboard-derived FICIs can vary with method (inoculum, endpoint, extract standardization) and may not fully predict in vivo interactions, we recommend completing FICI calculations by retrieving partner-MICs (or performing two-dimensional checkerboards) and confirming promising combinations with time-kill studies or PK/PD modeling prior to claiming clinical-relevant synergy (Bentley, 2024)

Science 337 , 839842 (2012)

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