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As the liver receives a larger bolus of HRT from the orally administered route compared to the transdermal route and different routes of administration lead to varying effects on circulating lipid profile, oral and transdermal HRT are likely to have distinct impacts on MASLD development (49)

These patients exhibited a decrease in H 2 S production and increase in cytosine methylation of the Cth promoter

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These appeared as having modulatory effects on the important systems, essentially implicated in cytoprotection [96,97,106], and eye functioning [94,95], NO-system, and prostaglandins systems [94,95,96,97,106]