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Under conditions of low glycolytic activity, FBP is scarce and the RCC2Rac1 complex remains intact, keeping Rac1 activation at a low level

Nonetheless, clinical trials involving both healthy individuals and those with mild cognitive impairment or AD are warranted to investigate whether melatonin can enhance the glymphatic systems efficacy in reducing brain concentrations of A and tau

79 NakamuraT.XiG.ParkJ.HuaY.HoffJ

Materials and Methods Experimental procedure Animals All experiments were approved by The Norwegian Animal Research Authority (NARA) and conducted in accordance with the Directive 2010/63/EU of the European Parliament