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As the deficiency progresses, more specific neurological signs and symptoms may develop, such as numbness or tingling in the hands and feet, difficulty walking, memory issues, or mood changes, such as irritability or depression
Silent information regulator-2 (Sir2)-like proteins (sirtuins) catalyze the removal of acetyl groups from acetylated proteins, utilizing ADP-ribose from NAD as an acceptor for acetyl groups
