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Description
Radical reaction of oxygen with PUFAs has been extensively reviewed by Gardner in 1989, 299 and the nature and formation mechanisms of nonenzymatic LA metabolites has been reviewed by Spiteller in 1998
Consequently, a crucial task will be to select the more active agents and integrate them effectively in well-designed clinical trials incorporating predictive biomarkers such as gene mutations, amplifications, and immunohistochemical c-MET overexpression

The causal mechanisms between excessive fructose consumption and lean MASLD have been extensively studied in animal models 16,48,76

Infrequently, signs and symptoms of glucocorticosteroid insufficiency may occur that require supplemental systemic corticosteroids
