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Melatonin is a hormone produced by the pineal gland, which regulates the body's sleep/wake cycle

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Specifically, recent research has suggested a bidirectional communication between metabolic dysfunction (loss of metabolic homeostasis) and cellular senescence ( In conclusion, the present results suggest new and unexpected links between fatigue, peripheral 5-HT, and L-carnitine in CFS and hypothyroidism, and offer testable hypotheses for future mechanistic and clinical studies

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