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In Vgat-ChR2 and Vgat-IRES-cre transgenic mice, we found for the first time that tesofensine inhibited a subset of LH GABAergic neurons, reducing their ability to promote feeding behavior, and chemogenetically silencing them enhanced tesofensines food-suppressing effects

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3.2 Mitochondrial dynamicsfission and fusion Mitochondria are highly dynamic organelles that influence cellular functions by constantly undergoing fusion and fission