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Vitamin B12 can be converted to coenzyme B12 in tissues, and as such is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine, a reaction which also requires folate

In contrast, oxidase-like nanozymes require simpler reaction conditions (avoiding the addition of H 2 O 2 )

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Unlike rodents, dogs share comparable lifespans, experience spontaneous diseases such as cancer and neurodegeneration, and develop diet-related conditions including obesity and diabetes, making them highly relevant for studying the long-term effects of antioxidant interventions