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A 12R-Lipoxygenase in Human Skin: Mechanistic Evidence, Molecular Cloning, and Expression

doi: 10.1016/j.jdermsci.2023.04.006 79 VianLLeMTGazanigaNKieltykaJLiuCPietropaoloGet al

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However, in cocaine addiction, most of the research focusing on mechanisms of action has implicated the modulation of the cystineglutamate antiporter by NAC as the most likely cause of benefit.26,82,83 Whereas there are similarities across these disorders with alterations to oxidative biology and neurotransmission, and changes in glutamate-dependent long-term potentiation and neuronal plasticity,84 perhaps the heterogeneity of the underlying pathologies, especially in brain regions implicated, may lead to the revelation of different actions of NAC depending on the disorder