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Several genes of chromosome 21 are directly implicated in oxidative stress, involving Cu, Zn-SOD (SOD1), ETS2 (ETS Proto-Oncogene 2) transcription factor, stress-inducible factor, protein S100, Down syndrome critical region gene 1 (DSCR1), amyloid precursor protein (APP), the -site APP cleaving enzyme 1 (BACE1) (Antonarakis et al

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Also, experimental in vitro evidence indicates that extracts of Lentinula edodes , exhibit antimicrobial activity against multidrug-resistant bacteria, including methicillin-resistant Staphylococcus aureus , with efficacy positively correlated to phenolic content and antioxidant capacity [46] Avinash et al