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Secondary salinity is caused by human activities such as poor irrigation practices, overuse of saline irrigation water, inadequate drainage, excessive fertilizer application, and deforestation, which collectively increase the salt burden in soils (Corwin, 2021

Erastin, as a small-molecule ferroptosis inducer, works by inhibiting the system Xc transporter-an amino acid antiporter responsible for exchanging extracellular cystine for intracellular glutamate (11)-leading to depletion of intracellular glutathione (GSH), indirectly inactivating glutathione peroxidase 4 (GPX4), and ultimately triggering ferroptosis (12)

For example, disturbances in glucose metabolism in the SN can be a marker for the diagnosis of PD

[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Kadri R., Shetty A., Parameshwar D., Kudva A.A., Achar A., Shetty J