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Description
The vast microbial genetic reservoir within the gut enables the gut microbiota to establish a mutualistic relationship with the host, performing critical functions such as fermenting dietary fibers to produce short-chain fatty acids (SCFAs), synthesizing vitamins (e.g., B12 and K), metabolizing xenobiotics, and competitively excluding pathogens [30]
However, broad interstudy and regional variations can be observed and it seems that the decrease in microbial diversity is a more relevant factor in AD-related dysbiosis
IL-4 and IL-10 are produced by Th2 cells 27 and are involved in the production of antibody IgE, which can further induce mast cells to release active mediators, such as histamine and cytokines, resulting in hypersensitivity 28
These reactions, including StevensJohnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are the most common severe ADRs in clinical practice
