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Our data provide another possible mechanism for this phenomenon, that enzymatic activity and/or protein-metabolite binding kinetics may account for time-dependent compound signal drift

mGluRs are divided into three groups based on their sequence homology, signal transduction pathways, and pharmacological profiles: Group I (mGluR1 and mGluR5), Group II (mGluR2 and mGluR3), and Group III (mGluR4, mGluR6, mGluR7, and mGluR8)

10.1016/j.ejphar.2011.05.038 31 IlicS.DrmicD.ZarkovicK.KolencD.CoricM.BrcicL.et al (2010)

Abstract The development of glucagon-like peptide 1 (GLP1) receptor agonists, including semaglutide and tirzepatide, has transformed the clinical management of overweight and obesity