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The significance of intracellular pH regulation to the function of pancreatic -cells cells is demonstrated by the fact that a high-fat diet is known to contribute to the development of type 2 diabetes

Mechanistically, acidic pH generates a protonated form of -KG that preferentially binds to LDHA 51

2005 Sep 7;31(5):329-34

Antitumor activity of ethanol extract from Hippophae rhamnoides L
