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glutathione transferase mitochondria metabolism in mitochondria. GS = glutathione, GS-T = Knockdown of microsomal glutathione S-transferase

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Brain 123 , 21182129 (2000)

glutathione transferase mitochondria metabolism in mitochondria. GS = glutathione, GS-T = Knockdown of microsomal glutathione S-transferase

The mutant forms of this protein fixate a much smaller amount of metals than the usual form, which results in the formation of an excess of peroxynitrite (ONOO ) affecting the motor neurons required for normal functioning, causing severe motor disorders (Pasinelli et al., 2004)

glutathione transferase mitochondria metabolism in mitochondria. GS = glutathione, GS-T = Knockdown of microsomal glutathione S-transferase

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glutathione transferase mitochondria metabolism in mitochondria. GS = glutathione, GS-T = Knockdown of microsomal glutathione S-transferase

A highly conserved tetralamellar // fold forms core of the enzyme appearing sandwich-like, made of two tightly packed antiparallel -sheets, one from each subunit, surrounded by two -helices (Okada et al., 2006)

glutathione transferase mitochondria metabolism in mitochondria. GS = glutathione, GS-T = Knockdown of microsomal glutathione S-transferase

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