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However, it is crucial to note that chronic antibiotic use may have adverse consequences, such as the emergence of antibioticresistant bacterial strains and potential metabolic disturbances (Yang, Li, et al
WNT signaling, a major bone anabolic mechanism, has been shown to activate several bioenergetic pathways in osteoblasts
Its activity needs different metallic cofactors (Fe, Zn, Cu and Mn) depending on the isoform, with specific subcellular distribution
, (~ 80 ) , L- ' ',
