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India's population-weighted PM2.5 level sat at 48.9 g/m in 2025, nearly ten times the WHO's annual guideline, and IQAir's 2025 World Air Quality Report found 66 of the world's 100 most polluted cities sit within India

This can lead to discontinuation syndrome, characterized by flu-like symptoms, mood swings, and other severe symptoms

Of note, there have been recent studies demonstrating that a MAFLD diagnosis is associated, on multivariate analysis, with an increased risk of type 2 diabetes mellitus in patients whose metabolic phenotype at diagnosis does not include type 2 diabetes mellitus, compared to a NAFLD diagnosis [50]

Further research is necessary to test whether a combination of these genetic polymorphisms alters intracellular ROS accumulation to explain the molecular basis for the genegene interactions