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Icariin (ICA) activates the SLC7A11/GPX4 signaling pathway, mitigating chondrocyte ferroptosis and protecting cartilage (Xiao et al., 2024)

These changes in fatty acids are indicative of a reduction in the production of inflammatory eicosanoids from AA and an increase in antiinflammatory mediators such as resolvins and protectins

However, despite the encouraging evidence, gaps in our knowledge remain to be filled in order to fully understand the mechanisms connecting NNMT with MetS-related disorders and to develop clinical agents against NNMT

A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis
