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They suggested that the alterations in 5-mC and 5-hmC may play an early role in the progression of AD [154]

Sickling also impairs the formation of membrane knobs containing a protein made by the parasite called PfEMP-1

Instead, they could emerge as intelligent, programmable platforms for disease detection, intervention, and systemic regulation

Future research necessitates optimizing stem cell sources and gene editing efficiency to advance these therapies from the laboratory to clinical practice, offering DN patients new hope beyond symptomatic management towards addressing disease etiology