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The SASP consists of a plethora of secreted factors, including pro-inflammatory cytokines, chemokines, growth factors, and extracellular matrix-degrading proteases, which profoundly influence the tissue microenvironment [56]

Additionally, high ChaC1 expression increases tumor cell sensitivity to anti-tumor drugs by inducing ER stress and ferroptosis (65,69,138)

Interestingly, sodium dichloroacetate (DCA) was shown in a study to help about half of patients with ME/CFS.[ref] The following is based on recent research that may be of interest to someone who has high lactate levels and suspects that a partial impairment of pyruvate dehydrogenase is possible

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