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This score uniquely integrates cholangiographic findings which are crucial for distinguishing PSC from AIHwith a family or personal history of autoimmunity

A study further reported that integrating metabolomic data with gut microbiome features significantly improves the sensitivity of early CRC detectionparticularly in high-risk populations [140]

Glutathione is an extremely important antioxidant

3 Mechanisms of mitochondrial dysfunction in Alzheimer's disease: oxidative stress, energy failure, calcium dysregulation, and mitochondrial dynamics 3.1 Oxidative stress Metabolic alterations are detectable in the early stage of AD, with impaired energy metabolism preceding cognitive decline (Lopez-Lee et al., 2024)