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PI3K/AKT/mTOR inhibitors The PI3K/AKT/mTOR pathway is a central regulator of CSC survival, metabolism, and therapeutic resistance, making it an attractive therapeutic target
Mechanistically, NNMT depletion reduced the consumption of methyl donors, increasing protein phosphatase2A (PP2A) methylation
doi: 10.1016/S0002-9610(02)00823-1
