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Past works have found that fisetin can inhibit senescence markers (p53, Bcl2, Cxcl1, and Mcp1)in DSS-induced UC in mice, upregulating the expression of micro RNAs (miRNAs) miR-149-5p, miR-96-5p, miR-34a-5p, and miR-30e-5p and the abundance of Akkermansia muciniphila , which is negatively correlated with senescence and inflammation [146]

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