hif-1 on glutathione ncbi Systematic and comprehensive insights into stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer Biology of HIF-1α | Cell
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Next, fumarate gets converted into malate and further into OAA that combine with another acetyl-CoA molecule to continue the TCA cycle

Gao C, Du Q, Li W, Deng R, Wang Q, Xu A, et al

Because only a small share of patients with high B12 are found to have cancer, the value does not function as a standalone screening test

Oxidation of acrolein may precede conjugation with GSH, thus forming acrylic acid
