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Oxidative stress promotes permeability of the blood-brain barrier: implications for the pathogenesis of Alzheimer's disease

Nonetheless, another study by Sun et al., which included 132 consecutive patients with acute ischaemic stroke due to anterior cerebral infarction, revealed that the abundance of SCFA-producing genera, including Bacteroides, Faecalibacterium, Roseburia, Ruminococcus, Coprococcus, and Butyricicoccus, was significantly decreased in the poor outcome cohort (defined as those with an mRS score 3)

They are not proven human outcomes

However, instead of being transported into mitochondria for oxidative metabolism, pyruvate is converted into lactate by LDHA, coupled with NADH/NAD+ interconversion (5)