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However, human clinical data on these wider applications are still preliminary

10.1371/journal.pone.0148424 PLoS One 4 BreaD.PoonC.BenakisC.LubitzG.MurphyM.IadecolaC.et al (2021)

Avoid introducing new skincare products, changing detergents, or significantly altering your diet

Out of the 25 articles, 21 showed an association between the use of metformin and vitamin B 12 deficiency, while 4 did not
