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Theriappan P, Gupta AK, Dhasarrathan P

Thus, the profound loss of nigral GSH, main storage form of cysteine, makes the free cysteine, which is increasingly transported into the cell, more likely to bind to oxidizing dopamine and formation DHBTs (dihydrobenzothiazines) by a series of consecutive reactions [63]

Detailed evidence is provided by the study of Zhu, that when neurexin-1 is transcriptionally repressed and activated in neurons in vitro, it is enriched around its promoter by synthesizing zinc-finger protein (ZFP) to histone methyltransferase (Ash1L) and histone marker H3K36me2, respectively, and that the transcriptional repression of neurexin-1 disappears when Ash1L is turned off [85]

Open Biol (2016) 6(6):160038 doi: 10.1098/rsob.160038 249 CunninghamKTFinlayCMMillsKHG