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Am J Physiol Renal Physiol 299: F905F916, 2010 [DOI] [PubMed] [Google Scholar] 61.Critchley JA, Nimmo GR, Gregson CA, Woolhouse NM, Prescott LF: Inter-subject and ethnic differences in paracetamol metabolism

Abnormal blood glucose levels can trigger increased blood viscosity and impaired blood circulation, resulting in insufficient blood supply to the kidney and eventually leading to the formation of blood stasis blocking the collaterals (49)

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There is growing evidence that immune dysregulation and neuroinflammation are central to its pathogenesis, with the microbiota-gut-brain (MGB) axis playing a critical role